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The studies describing the immunological characterization of tumors and the identification of biomarkers associated with the response to immunotherapies that underlie the ONCO-ND1 platform are described in some of the publications, largely joint between the research groups of Prof. Michele Ceccarelli, Prof. Davide Bedognetti, and Prof. Antonio Iavarone.
- publications
Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response
Roelands, J., W. Hendrickx, G. Zoppoli, R. Mall, M. Saad, K. Halliwill, G. Curigliano, D.
Rin- chai, J. Decock, L. G. Delogu, M. Ceccarelli, and D. Bedognetti (2020).
Oncogenic states dictate the prognostic and predictive connotations of intratumoral
immune response. Journal for immunotherapy of cancer 8(1).
Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis.
Hendrickx, W., I. Simeone, S. Anjum, Y. Mokrab, F. Bertucci, P. Finetti, G. Curigliano, B.
Seliger, L. Cerulo, S. Tomei, L. G. Delogu, C. Maccalli, E. Wang, L. D. Miller, F. M.
Marincola, M. Ceccarelli, and D. Bedognetti (2017). Identification of genetic
determinants of breast cancer immune phenotypes by integrative genome-scale
analysis. OncoImmunology 6(2), e1253654
The combination of neoantigen quality and T lymphocyte infiltrates identifies glioblastomas with the longest survival
Zhang, J., F. P. Caruso, J. K. Sa, S. Justesen, D.-H. Nam, P. Sims, M. Ceccarelli, A.
Lasorella, and A. Iavarone (2019). The combination of neoantigen quality and T
lymphocyte infiltrates identifies glioblastomas with the longest survival. Communications
Biology 2(1), 135.
A balance score between im- mune stimulatory and suppressive microenvironments identifies mediators of tumor immunity and predicts pan-cancer survival
Turan, T., S. Kongpachith, K. Halliwill, J. Roelands, W. Hendricks, F. M. Marincola, T. J.
Hudson, H. J. Jacob, D. Bedognetti, J. Samayoa, and M. Ceccarelli. A balance score
between im- mune stimulatory and suppressive microenvironments identifies mediators
of tumor immunity and predicts pan-cancer survival. British Journal of Cancer (2020).
Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop
Bedognetti D, Ceccarelli M, et al . Toward a comprehensive view of cancer immune
responsiveness: a synopsis from the SITC workshop. Journal for Immunotherapy of
Cancer. 2019 May 22;7(1):131
Evolution of Metastases in Space and Time under Immune Selection
Angelova M, Mlecnik B, Vasaturo A, Bindea G, Fredriksen T, Lafontaine L, Buttard B,
Morgand E, Bruni D, Jouret-Mourin A, Hubert C, Kartheuser A, Humblet Y, Ceccarelli M,
Syed N, Marincola FM, Bedognetti D, Van den Eynde M, Galon J. Evolution of
Metastases in Space and Time under Immune Selection. Cell 2018 Oct
18;175(3):751-765.
he immunologic constant of rejection classification refines the prognostic value of conventional prognostic signatures in breast cancer
Bertucci F, Finetti P, Simeone I, Hendrickx W, Wang E, Marincola FM, Viens P,
Mamessier E, Ceccarelli M, Birnbaum D, Bedognetti D. The immunologic constant of
rejection classification refines the prognostic value of conventional prognostic signatures
in breast cancer. British Journal of Cancer. 2018 Nov;119(11):1383-1391.
The immune landscape of cancer.
Thorsson V, Gibbs,… Bedognetti D, et al.. The immune landscape of cancer.
Immunity, 2018
Prediction of response to anticancer immunotherapy using gene signatures
Wang E, Bedognetti D, Marincola FM. Prediction of response to anticancer
immunotherapy using gene signatures. Journal of Clinical Oncology 2013
Ligand Significantly Augments Immune Responses to a Dendritic Cell Targeting anti-DEC-205-NY-ESO-1 Vaccine through Expansion of Dendritic Cell Subsets
Bhardwaj N,…Bedognetti et al. Flt3 Ligand Significantly Augments Immune Responses
to a Dendritic Cell Targeting anti-DEC-205-NY-ESO-1 Vaccine through Expansion of
Dendritic Cell Subsets, Nature Cancer (in press).
Germline genetic contribution to the immune landscape of cancer
Sayaman R, Saad M, Thorsson V, Wouter Hendrickx, Roelands J, Mokrab Y, Farshidfar
F, Kirchhoff T, Sweis RS, Bathe OD, Porta-Pardo E, Campbell MJ, Stretch C, Hu D,
Huntsman S, Graff RE, Syed N, Radvanyi L, Shelley S, Wolf D, Marincola FM,
Ceccarelli M, Galon J, …., Ziv E, Bedognetti D. Germline genetic contribution to the
immune landscape of cancer. Immunity (under revision), preprint available in Biorxiv
A multi-layer molecular fresco of the immune diversity across hematologic malignancies
Bedognetti D. A multi-layer molecular fresco of the immune diversity across
hematologic malignancies. Cancer Cell, September 2020
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
Ceccarelli…,Iavarone A, Verhaak R, et al. Molecular Profiling Reveals Biologically
Discrete Subsets and Pathways of Progression in Diffuse Glioma, Cell, 2016
Transcriptomic profiles conducive to immune-mediated tumor rejection in human breast cancer skin metastases treated with Imiquimod
Rozenblit M…Marincola F, Bedognetti D, Adams S. Transcriptomic profiles conducive
to immune-mediated tumor rejection in human breast cancer skin metastases treated
with Imiquimod. Scientific Reports, 2019
CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2
Bedognetti D, Hendrickx W, Ceccarelli M, Miller LD, Seliger B. Curr Opin Immunol. 2016
Bedognetti D, …Rosenberg SA, Marincola FM. CXCR3/CCR5 pathways in metastatic
melanoma patients treated with adoptive therapy and interleukin-2. British Journal of
Cancer 2013
expression is associated with immune signatures and basal-like phenotype in breast cancer
Insaldi E., Ballestrero A, Bedognetti D, Zoppoli G. Schlafen-11 expression is
associated with immune signatures and basal-like phenotype in breast cancer. Breast
Canc Res and Treat, 2019.